ME

The hidroquinina therapy is best known and most effective in the depigmentation of the skin and mixed-type melasma.

How it works:

- The HQ inhibits the conversion of tyrosine to melanin

- The HQ inhibits the formation of melanosomes and / or increased degradation of melanosomes.

- The HQ inhibits DNA and RNA synthesis of melanocytes.

As a result, only cells with intense tyrosinase activity are affected by the HQ. Tyrosinase is active only in the epidermis. In dermal melanin is not presented, therefore, dermal melanin is resistant to HQ.

The hidroquinina is obtained in very different concentrations. Anything above the 2% concentration should be administered with a prescription. The higher the concentration, the more effective the formula.

A higher concentration of HQ presents a higher risk of irritation and those with darker complexion, a higher chance of subsequent inflammation, hyperpigmentation (darkening of color where there was irritation and inflammation).

Tretinoin may be used alone or in combination with HQ treatment. Tretinoin may improve the effectiveness of HQ to allow for better absorption and preventing the oxidation of HQ.

Azelaic acid is another possibility. However, its disadvantages exceed its abilities. While the AZA does not inhibit tyrosine and acts on hyperactive melanocytes and subnormal, is cytotoxic (deadly) to the pigment cells of the skin and, especially, anti-proliferative effects (slows the growth and metabolism of cells).

Other compounds that work well include kojic acid, bearberry extract (Bearberry) and vitamin C, which inhibits melanin production.

Chemical peels can be used to help treat melasma, but it is recommended only for patients with light skin. For those with dark skin, there is a risk of hyperpigmentation and peeling post worsening of melasma.

With laser therapy, it is important to distinguish between true lasers and intense light devices. The laser, like the Q, ND, the YAG and Ruby produce unsatisfactory results. The device is not intense laser light but is often referred to as such.

The results obtained with the IPL are more successful than traditional laser therapy and can often help melasma cases that are resistant to local treatment.

Mandelic acid, alpha-hydroxy acid derived from almonds, has been used successfully in the treatment of melasma. It is recommended as an alternative for those who are sensitive or resistant to hydroquinone and other whitening therapies.

It can also be used as an adjunct to the hydroquinone to improve performance. It is the only local treatment has been shown to improve dermal melasma.

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